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. 2022 Dec 22;21(3):629–638. doi: 10.1016/j.jtha.2022.11.033

Figure 1.

Figure 1

Coagulation–related transcription changes with coronavirus 2019 (COVID-19) infection. (A) scRNA-seq analysis on PBMCs. Controls included individual samples from 6 age–matched subjects. COVID-19 samples included 2 samples per patient taken 7 days apart from 12 severe COVID-19 patients, 6 of whom died. Shown are the means and standard error of mean (SEM) vs controls for the pooled COVID-19 samples. Procoagulants in green; anticoagulants in yellow; profibrinolytic in blue; antifibrinolytics in orange. (B) Cell types proportional expression of transcripts in COVID-19 samples. (C) Bulk RNA-seq analysis on sorted CD14+ monocytes. This analysis included individual samples from 10 age–matched controls and 10 severe COVID-19 patients. Shown are the means and SEM vs controls for COVID-19 samples. Samples and patients in (A) and (C) did not overlap. Mann–Whitey test P values ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. Dashed red line represents the level for controls that equals 1.