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. 2022 Dec 22;21(3):629–638. doi: 10.1016/j.jtha.2022.11.033

Figure 2.

Figure 2

Tissue factor (TF) (F3) transcription is dependent on disease severity. (A and B) Bulk RNA sequencing analysis of sorted CD14+ monocytes. (A) CD14+ monocytes IL-6 gene transcripts are elevated in severe but not mild COVID-19 disease patients. (B) CD14+ monocytes TF (F3 gene) transcripts are elevated in severe but not mild COVID-19 disease patients. (C) Bronchoalveolar lavage fluid (BALF) IL-6 gene transcripts are elevated in severe but not moderate COVID-19 disease patients. (D) Epithelial cell numbers are increased in BALF from patients with severe COVID-19 disease. (E) Epithelial cell TF (F3 gene) transcripts are elevated in severe but not moderate COVID-19 disease patient plasmas. (F) Macrophage TF (F3 gene) transcripts are elevated in severe but not moderate COVID-19 disease. Mann–Whitney test P values as indicated in Figure 1, with red denoting vs controls, blue denoting vs mild or moderate, and black denoting vs combined controls and mild or moderate.