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. 2022 Dec 21;10:188. doi: 10.1186/s40478-022-01494-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Cell type deconvolution analysis of snRNA-seq data and Visium SRT data from human MTG. (A) Manual annotations of six cortical layers and the adjacent WM in CT (CT-1) and AD (AD-1) human MTG, and spatial maps of the cell-type-specific distributions of seven main cell types (Astro, Endo, Exc, Inh, Micro, OPC and Oligo) [37] among spots and layers corresponding to these two cases using Cell2location (see details in Methods). Spots enriched for each cell subpopulation are shown in brown, which is divided into high and low expression based on the proportion of each individual cell subpopulation. (B) Stack bar plots highlight the proportion of seven main cell types in layers I-VI (L1-L6) and the adjacent WM of CT-1 and AD-1. NS, noise spots; Astro, astrocytes; Endo, endothelial cells; Exc, excitatory neurons; Inh, inhibitory neurons; Micro, microglia; Oligo, oligodendrocytes; and OPC, oligodendrocyte precursor cells