Table 3.
Determinants of Survival in Preterm neonates with Respiratory distress syndrome
| Factors | Preterm Survival Status | |||||
|---|---|---|---|---|---|---|
| Censored N (%) | Died N (%) | CHR 95% CI | P-value | AHR 95% CI | P-value | |
| Sex | ||||||
| Male | 93 (73.2) | 34 (26.8) | 1.45 (0.92–2.27) | 0.11 | ||
| Female | 76 (63.9) | 43 (36.1) | 1 | – | – | |
| Gestational Age | ||||||
| < 32 weeks | 85 (60.3) | 56 (39.7) | 2.16 (1.31–3.56) | 0.003* | 1.61 (0.91–2.85) | 0.10 |
| ≥ 32–37 weeks | 84 (80) | 21 (20) | 1 | 1 | ||
| Birth weight (grams) | ||||||
| < 1500 | 91 (59.9) | 61 (40.1) | 2.45 (1.43–4.20) | 0.001* | 2.11 (1.16–3.85) | 0.015* |
| ≥ 1500 | 78 (83) | 16 (17) | 1 | 1 | ||
| 5th minute APGAR Score | ||||||
| > 7 | 116 (74.4) | 40 (25.6) | 1 | 1 | ||
| 4–7 | 48 (60) | 32 (40) | 1.71 (1.07–2.72) | 0.024* | 2.18 (1.33–3.56) | 0.002* |
| Not known | 5 (50) | 5 (50) | 2.22 (0.87–5.61) | 0.09 | 1.97 (0.74–5.21) | 0.17 |
| Age at admission | ||||||
| < 1 hour | 69 (77.5) | 20 (22.5) | 1 | 1 | ||
| ≥ 1 hour | 100 (63.7) | 57 (36.3) | 1.73 (1.04–2.88) | 0.036* | 1.56 (0.91–2.67) | 0.10 |
| Admission saturation | ||||||
| ≥ 90% | 115 (73.7) | 41 (26.3) | 1 | 1 | ||
| < 90% | 54 (60) | 36 (40) | 1.69 (1.08–2.64) | 0.022* | 1.50 (0.95–2.38) | 0.09 |
| Admission SAS | ||||||
| ≥ 6 (severe) | 50 (75.8) | 16 (24.2) | 0.79 (0.43–1.46) | 0.46 | ||
| 4 to 5 (moderate) | 51 (61.4) | 32 (38.6) | 1.36 (0.82–2.25) | 0.23 | ||
| 1 to 3 (mild) | 68 (70.1) | 29 (29.9) | 1 | – | – | |
| Admission temp (°C) | ||||||
| ≥ 36.5 | 81 (74.3) | 28 (25.7) | 1 | – | – | |
| < 36.5 | 88 (64.2) | 49 (35.8) | 1.46 (0.92–2.32) | 0.11 | ||
| Admission RBS | ||||||
| ≥ 2.6 mmol/l | 124 (72) | 48 (28) | 1 | – | – | |
| < 2.6 mmol/l | 45 (61) | 29 (39) | 1.54 (0.97–2.43) | 0.07 | ||
| 6th hour temp (°C) | ||||||
| ≥ 36.5 | 123 (73.7) | 44 (26.3) | 1 | 1 | ||
| < 36.5 | 46 (58.2) | 33 (41.8) | 1.67 (1.07–2.63) | 0.025* | 1.02 (0.63–1.66) | 0.92 |
| 6Th hour RBS | ||||||
| ≥ 2.6 mmol/l | 151 (69.3) | 67 (30.7) | 1 | – | – | |
| < 2.6 mmol/l | 18 (64.3) | 10 (35.7) | 1.23 (0.63–2.38) | 0.55 | ||
| 6th hour saturation | ||||||
| ≥ 90% | 166 (69.7) | 72 (30.3) | 1 | 1 | – | |
| < 90% | 3 (37.5) | 5 (62.5) | 3.03 (1.22–7.52) | 0.017* | 4.45 (1.68–11.7) | 0.003* |
| 6th hour SAS | ||||||
| ≥ 6 (severe) | 37 (74) | 13 (26) | 0.87 (0.46–1.67) | 0.68 | ||
| 4–5 (moderate) | 56 (63.6) | 32 (36.4) | 1.25 (0.76–2.04) | 0.38 | ||
| 1–3 (mild) | 76 (70.4) | 32 (29.6) | 1 | – | – | |
| Surfactant | ||||||
| Yes | 38 (77.6) | 11 (22.4) | 1 | – | – | |
| No | 131 (66.5) | 66 (33.5) | 1.61 (0.85–3.0) | 0.15 | ||
| Place of Delivery | ||||||
| MNH | 109 (73.2) | 40 (26.8) | 1 | – | – | |
| Others | 60 (62) | 37 (38) | 1.47 (0.94–2.31) | 0.09 | ||
| Mode of Delivery | ||||||
| Vaginal | 108 (66.7) | 54 (33.3) | 1 | – | – | |
| Caesarian Section | 61 (2.6) | 23 (27.4) | 0.82 (0.50–1.34) | 0.43 | ||
| Antenatal steroid | ||||||
| Received | 26 (92.9) | 2 (7.1) | 1 | 1 | ||
| Not received | 143 (65.6) | 75 (34.4) | 5.35 (1.31–21.8) | 0.019* | 4.59 (1.11–18.9) | 0.035* |
| PROM > 18 hours | ||||||
| Yes | 51 (62.2) | 31 (37.8) | 1.38 (0.88–2.18) | 0.17 | ||
| No | 118 (72) | 46 (28) | 1 | – | – | |
| Maternal Fever | ||||||
| Yes | 20 (60.6) | 13 (39.4) | 1.42 (0.78–2.58) | 0.25 | ||
| No | 149 (70) | 64 (30) | 1 | – | – | |
* = significant at P < 0.05, CHR Crude Hazard ratio, AHR Adjusted Hazard ratio, 95% CI 95% Confidence Interval