Fig. 3.

Reclassification outcomes for 718 MSH2 missense variants. Flow diagram showing starting and final variant classifications; in total, 74% of the missense VUSs have sufficient evidence to enable potential reclassification to benign (B), likely benign (LB), likely pathogenic (LP) or pathogenic (P). A subset of remaining VUSs had intermediate function scores (n=19) or had abnormal function scores but lacked sufficient lines of evidence (or had conflicting evidence) and so remain as VUS (n=12)