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. 2022 Dec 21;17:557. doi: 10.1186/s13018-022-03449-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — EBLN3P sponge miR-200a-3p in MTX resistance osteosarcoma. A The potential binding site of miR-200a-3p with EBLN3P. B The expression of miR-200a-3p was significantly decreased in the osteosarcoma tissue compared to adjacent tissues. C The expression of miR-200a-3p in osteosarcoma patients of GSE65071 and GSE79181 demonstrated significantly downregulated expression in osteosarcoma patients or osteosarcoma patients with relapse. D Knockdown of EBLN3P (EBLN3P-si) increased miR-200a-3p expression in MTX-resistant osteosarcoma cell line MNNG/HOS-MTXr and MG63-MTXr. E The luciferase activity of the WT- EBLN3P sequence was suppressed by the mimic of miR-200a-3p while the activity did not affect the Mut- EBLN3P (mutant EBLN3P) sequence compared with negative control sequence of miR-200a-3p (miR-200a-3p NC). **p < 0.01