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. 2022 Dec 21;17:557. doi: 10.1186/s13018-022-03449-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — EBLN3P increased MTX-resistance of osteosarcoma cells by enhancing miR-200a-3p/OGT axis. A Upregulation of EBLN3P (EBLN3P OE) increased the invasion ability of MNNG/HOS and MG63 cells. B Column comparison of invaded cells in MNNG/HOS and MG63 cells. **p < 0.01. C and D Effect of blocking OGT on EBLN3P upregulated cells was evaluated. Blocking OGT by OGT-si decreased the resistant effect of EBLN3P on MTX in MNNG/HOS and MG63 cells. *p < 0.05, **p < 0.01, compared with vector; ^#p < 0.05, ^##p < 0.01, compared with EBLN3P OE + OGT-si. E Western blot analyzing the effect of EBLN3P, miR-200a-3p, and OGT on MNNG/HOS cells. Upregulation of EBLN3P leads to increased expression of OGT, Vimentin, and N-cadherin while decreasing the expression of E-cadherin. Further upregulation of miR-200a-3p or knockdown OGT (OGT-si) decreased the expression of OGT, Vimentin, and N-cadherin. *p < 0.05, **p < 0.01, compared with vector; ^#p < 0.05, ^##p < 0.01, compared with EBLN3P OE