Table 2.
Association between Bisphenols and sex hormones (Total Testosterone, Estradiol, Sex hormone-binding globulin) among the US males in NHANES 2011-2016
| Bisphenols | Total Testosterone(ng/dL) β(95%CI) |
Estradiol (pg/ml) β(95%CI) |
Sex hormone-binding globulin (SHBG) (nmol/L) β(95%CI) |
|||
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | |
| BPA (Continuous) | -0.156 (-1.248, 0.936) 0.779 | 0.611 (-0.805, 2.026) 0.398 | -0.009 (-0.078, 0.061) 0.807 | -0.039 (-0.143, 0.064) 0.456 | 0.135 (-0.024, 0.294) 0.096 | 0.364 (0.158, 0.571) 0.001 |
| BPA (Quartiles) | ||||||
| Q1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Q2 | -6.109 (-26.68, 14.46) 0.561 | -6.314 (-25.840, 13.213) 0.526 | -1.430 (-2.835, -0.025) 0.046 | -1.534 (-2.948, -0.120) 0.034 | -3.933 (-7.329, -0.537) 0.024 | 0.746 (-2.209, 3.699) 0.621 |
| Q3 | -28.229 (-48.657, -7.801) 0.007 | -23.175 (-43.634, -2.715) 0.027 | -1.129 (-2.529, 0.272) 0.114 | -1.667 (-3.154, -0.180) 0.028 | -5.136 (-8.482, -1.791) 0.003 | -1.784 (-4.856, 1.289) 0.255 |
| Q4 | -15.770 (-36.341, 4.801) 0.1335 | -6.709 (-29.146, 15.729) 0.558 | 0.023 (-1.390, 1.436) 0.975 | -0.876 (-2.499, 0.747) 0.290 | 0.228 (-3.148, 3.604) 0.895 | 4.072 (0.746, 7.397) 0.017 |
| P for trend | 0.168 | 0.924 | 0.369 | 0.938 | 0.252 | 0.005 |
| BPS (Continuous) | -0.165 (-1.511, 1.181) 0.810 | 0.079 (-1.162, 1.321) 0.900 | -0.011 (-0.085, 0.064) 0.774 | -0.018 (-0.091, 0.056) 0.635 | 0.276 (0.068, 0.484) 0.009 | 0.250 (0.071, 0.429) 0.006 |
| BPS (Quartiles) | ||||||
| Q1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Q2 | -27.161 (-54.670, 0.377) 0.053 | -17.705 (-43.628, 8.218) 0.181 | 0.706 (-0.829, 2.241) 0.366 | 0.306 (-1.236, 1.849) 0.697 | -4.067 (-7.821, -0.313) 0.034 | -2.195 (-5.465, 1.074) 0.188 |
| Q3 | 11.620 (-16.537, 39.776) 0.419 | 20.794 (-6.427, 48.016) 0.135 | 2.067 (0.496, 3.636) 0.011 | 1.738 (0.118, 3.357) 0.036 | -1.482 (-5.312, 2.349) 0.448 | 1.333 (-2.088, 4.754) 0.445 |
| Q4 | -11.482 (-39.870, 16.906) 0.428 | -8.295 (-36.676, 20.085) 0.567 | 0.503 (-1.079, 2.086) 0.533 | 0.140 (-1.548, 1.827) 0.871 | -4.017 (-7.868, -0.165) 0.041 | -1.678 (-5.254, 1.897) 0.358 |
| P for trend | 0.963 | 0.775 | 0.856 | 0.592 | 0.222 | 0.549 |
| BPF (Continuous) | 0.078 (-0.494, 0.649) 0.790 | 0.575 (0.047, 1.103) 0.033 | 0.017 (-0.015, 0.049) 0.295 | 0.010 (-0.022, 0.042) 0.542 | 0.008 (-0.066, 0.083) 0.825 | 0.025 (-0.039, 0.089) 0.444 |
| BPF (Quartiles) | ||||||
| Q1+2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Q3 | -8.203 (-30.453, 14.047) 0.470 | -13.633 (-34.227, 6.963) 0.195 | -0.278 (-1.518, 0.961) 0.660 | -0.372 (-1.599, 0.855) 0.553 | -0.941 (-3.914, 2.032) 0.535 | -2.453 (-4.997, 0.090) 0.059 |
| Q4 | 11.352 (-10.122, 32.825) 0.300 | 18.062 (-2.399, 38.522) 0.084 | 1.446 (0.255, 2.637) 0.017 | 1.172 (-0.043, 2.384) 0.059 | -1.266 (-4.153, 1.622) 0.390 | -1.659 (-4.188, 0.870) 0.199 |
| P for trend | 0.451 | 0.223 | 0.634 | 0.468 | 0.527 | 0.058 |
Model 1: crude model
Model 2: adjusted for age, race, BMI, poverty income ratio (PIR), smoking status, urinary creatinine, and time of sample collection, six-month time period.
95%CI 95% Confidence interval