Table 1.
Summary of proteins with significant changes in both protein and phosphosite abundance in NEK5-overexpressing cells
| Protein | Protein function | Protein FC | Sites | Site FC |
|---|---|---|---|---|
| CCDC86 | RNA binding | 1.38 | S21 | 2.77 |
| S66 | 14.64 | |||
| DTD1 | DNA replication | 1.76 | S194 | 3.48 |
| S197 | 4.27 | |||
| TRIP12 | Ubiquitin fusion, degradation and DNA repair | 1.59 | S1317 | 4.15 |
| S1322 | 4.15 | |||
| S1329 | 3.13 | |||
| RIC8A | G-alpha signalling and mitosis | 2.38 | Y435 | 3.80 |
| ARHGEF2 | Cell motility and cell cycle regulation | 1.48 | S174 | 2.97 |
| RFC1 | DNA replication | 2.22 | Y67 | 0.32 |
| KAT7 | DNA replication and transcription | 1.56 | S100 | 0.28 |
| S102 | 0.28 | |||
| S99 | 0.18 | |||
| T104 | 0.19 | |||
| T97 | 0.19 | |||
| POLA2 | DNA replication | 2.52 | S147 | 0.20 |
| T156 | 0.20 | |||
| FOXK1 | Transcriptional regulator | 1.93 | S257 | 0.19 |
| CLASP1 | Microtubule dynamics | 1.34 | S594 | 0.16 |
| ZMYM4 | Cell morphology and cytoskeletal organisation | 0.40 | S1064 | 0.08 |