Fig. 5.

Age determines hippocampal transcriptomic response to obesity. Heat map of hippocampal gene expression counts measured by NanoString nCounter for differentially expressed genes (diet*age interaction by mixed-effects model, P-value < 0.05); adult standard diet (SD; teal, first column), adult high-fat diet (HFD; red, second column), aged SD (blue, third column), and aged HFD (orange, fourth column). Genes (rows) were hierarchically clustered, while columns include animals ordered by replicate number (n = 7–8 per group). Color represents relative expression levels of normalized counts for each gene across all samples from low expression (blue) to high expression (red)