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. 2022 Dec 22;26:401. doi: 10.1186/s13054-022-04283-8

Table 2.

Primary and secondary outcomes

Follow-up group, n = 63 Fluid bolus group, n = 67 Follow-up group vs Fluid bolus group (95% CI) P valuec
Primary outcome
Number of patients with doubled urine output (%) 10 (15.9) 22 (32.9) 0.49* (0.23–0.71) 0.026
Secondary outcomes
Change in individual urine output, median [IQR], mL − 7 [− 19 to 17] 19 [0–53] − 23** (− 36 to − 10) 0.001
Duration of consecutive oliguria, median [IQR], hoursa 4 [2–8] 2 [0–6] 2** (0–4) 0.038
Cumulative fluid balance 6 h post-randomization, median [IQR], mLb 678 [518–1029] 1071 [822–1505] -387** (− 635 to − 213) < 0.001

Data included from all 130 patients

*Risk ratio

**Median difference

aUrine output < 0.5 mL/kg/h, data collected to 30d post-randomization or ICU discharge if earlier

bIncluding fluid input and urine output

cAdjusted (sepsis and acute kidney injury) median difference or risk ratio with 95% CIs