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. 2022 Dec 22;21(1):94–100. doi: 10.1016/j.jtha.2022.10.013

Figure 1.

Figure 1

Platelet coverage in post-COVID syndrome. (A) Representative images (20× magnification) of platelets labelled with DiOC6 bound to collagen, anti-von Willebrand factor (VWF) A3, or VWF, after 3 minutes of flow at 1800/s in patients with post-COVID syndrome (PCS) (n = 21) vs healthy controls (n = 45). (B) Platelet surface coverage on microchannels coated with collagen, anti-VWF A3, or VWF, after 3 minutes of perfusing whole blood from healthy controls (black, n = 45) vs patients with PCS (red, n = 21 for collagen, anti-VWF A3, n = 15 for VWF-coated channels), at 1800/s. Data displayed as mean±SD and analyzed using unpaired Student’s t-test with Welch’s correction. ∗∗p < .01. (C) Correlation between platelet coverage on collagen and ADAMTS13 activity levels. Data analyzed using Pearson correlation coefficients. (D) Correlation between platelet coverage on anti-VWF A3 and VWF(Ag):ADAMTS13 ratio (i) or VWF antigen levels (ii). Data was analyzed using Pearson correlation coefficients.