TABLE 1.
Demographics and cognitive test scores according to the diagnosis
| AD (N = 7) | HC (N = 7) | P value | |
|---|---|---|---|
| Mean (SD) or N (%) | |||
| Sex, No of male participants (%) | 4 (57.1%) | 4 (57.1%) | 1 |
| Age | 70.7 (9.11) | 71.1 (6.64) | 0.897 |
| APOE ɛ4, No of positive participants (%) | 5 (71.4%) | 1 (14.3%) | 0.031 |
| Education years | 13.7 (2.14) | 14.7 (3.30) | 0.674 |
| CDR_Global, No of participants (%) |
CDR = 0.5: 4 (57.1%) CDR = 1: 3 (42.9%) |
CDR = 0: 7 (100%) | N/A |
| MMSE score | 18.7 (5.12) | 28.4 (1.51) | 0.002 |
| ADAS‐Cog score | 24.1 (8.45) | 3.26 (1.24) | 0.002 |
| Plasma p‐tau181 (pg/mL) | 4.13 (0.993) | 1.12 (0.207) | < 0.001 |
Note: Differences in the baseline characteristics between the AD and HC groups were analyzed by the Mann–Whitney U test for continuous variables and the chi‐squared test for dichotomous variables.
Abbreviations: ADAS, Alzheimer’s Disease Assessment Scale Cognitive Behavior Section; AD, Alzheimer’s disease; CDR, Clinical Dementia Rating; HC, healthy control; MMSE, Mini‐Mental State Examination; N/A, not applicable; p‐tau181, phosphorylated tau at residue 181; SD, standard deviation.