TABLE 1.

Formula for individual fitness score

	Nontreatment‐resistant schizophrenia	Treatment‐resistant schizophrenia
Clozapine or ECT	NA	CLZ(+)	CLZ(−)
			ECT(+)	ECT(−)
		0	−20	−60
SGA monotherapy, less than MTD	0‐5		0	0
FGA monotherapy, less than MTD			−5	−5
SGA monotherapy, <1.5 times of MTD	−25		−25	−25
FGA monotherapy, <1.5 times of MTD	−30		−30	−30
SGA monotherapy, more than 1.5 times of MTD	−50		−50	−50
FGA monotherapy, more than 1.5 times of MTD	−55		−55	−55
SGA + SGA, total CPZ equivalent <1000	−25	−30	−25	−25
SGA + FGA, total CPZ equivalent <1000	−30		−30	−30
FGA + FGA, total CPZ equivalent <1000	−35	−40	−35	−35
SGA + SGA, total CPZ equivalent ≧1000, <2000	−35		−35	−35
SGA + FGA, total CPZ equivalent ≧1000, <2000	−40		−40	−40
FGA + FGA, total CPZ equivalent ≧1000, <2000	−45		−45	−45
SGA + SGA, total CPZ equivalent ≧2000	−50		−50	−50
SGA + FGA, total CPZ equivalent ≧2000	−55		−55	−55
FGA + FGA, total CPZ equivalent ≧2000	−60		−60	−60
Combination therapy with 3 or more SGAs	−65		−65	−65
Combination therapy with 3 or more SGAs + FGAs	−70	−70	−70	−70
No antipsychotc prescription	−90	−90	−90	−90
No daily prescription (as needed prescrioption only)	−60	−60	−60	−60
Concomitant use of antidepressants, anxiolytics, hypnotics, mood stabilizers, antiepileptic drugs, and other psychotropic drugs (except dopaminergic and anticholinergic drugs)	1 drug −15, 2 drugs −35, 3 drugs or more −55 a
Concomitant use of dopaminergic drugs (dopaminergic antiparkinsonian drugs, psychostimulants)	−80 for each
Concomitant use of anticholinergic drugs	<2 mg −5, <6 mg −10, >6 mg −30

Note: The individual fitness score was calculated by subtracting the number of points corresponding to each item from 100 points. 0 or less was set to zero.

Abbreviations: ECT, electroconvulsive therapy; FGA, first‐generation antipsychotic; MTD, maximum therapeutic dose; SGA, second‐generation antipsychotic.

^a In the case of clozapine, Li −5, Li + one drug −25, Li + two or more drugs −45.