Fig. 5.

Comparison of IC₅₀ curves for three cell lines of different maturation ages. IC₅₀ curves and values for drugs with diffusion coefficients of D_γ = 1μm²/s (blue), 10⁻²μm²/s (red), and 10⁻⁴μm²/s (magenta) in the monolayer culture model (top) and the cross section though the spheroid culture model (bottom) for the maturation times of a A^mat = 18 h, b A^mat = 30 h, and c A^mat = 50 h. All data are presented after 72 h of the simulated time