Fig. 7.

Comparison of IC₅₀ curves for three cell lines of different maturation ages. IC₅₀ curves for drug diffusion coefficient of D_γ = 10⁻⁴μm²/s and cell maturation ages of a A^mat=18 h, b A^mat=30 h, and c A^mat=50 h, in 2D cell monolayer culture (blue) and 3D cell spheroid culture (red). All data are presented after 72 h of the simulated time