Table 2.

Changes in plaque burden and lipid content over 2 years by treatment groups.

	All subjects (N=156)		Statin alone (n=89)		Statin + ERN (n=67)		P-value for between-group differences†
Variable	Baseline	Follow-up	Baseline	Follow-up	Baseline	Follow-up
Mean lumen area, mm2	43 ± 15	44 ± 16	43 ± 16	43 ± 16	43 ± 15	44 ± 15	0.85
Mean wall area, mm2	30 ± 8	31 ± 8*	30 ± 8	31 ± 8*	30 ± 8	31 ± 8*	0.68
Mean outer wall area, mm2	73 ± 20	74 ± 20*	73 ± 21	74 ± 21*	73 ± 19	75 ± 19*	0.51
Lipid core volume, mm3	31 (17 – 71)	27 (14 – 60)	29 (16 – 53)	26 (15 – 50)	32 (18 – 98)	32 (15 – 98)	0.50
Lipid core, %	7 (4 – 12)	6 (3 – 11)*	6 (4 – 11)	5 (3 – 9)*	9 (5 – 16)	7 (4 – 19)	0.44

ERN: extended-release niacin. Values are mean ± standard deviation or median (inter-quartile range) unless otherwise specified;

^*: p<0.05 by Wilcoxon signed-rank test comparing baseline and follow-up measurements;

^†Wilcoxon rank-sum test comparing annualized changes from baseline to follow-up between treatment groups.