Table 2. Past Self-Deprotection Occurrences of TZP API Instability during Storage.
TZP API intermediate and model peptide nomenclature | storage temp (°C) | storage time (days) | sample status | deprotection conversion (%) |
---|---|---|---|---|
Fmoc-Ala-Pro-Pro-Pro-Ser-resin | 3 | 242 | wet | 82 |
Fmoc-Ala-Pro-Pro-Pro-Ser-resin | –20 | 243 | dry | 8 |
Fmoc-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-resin | –20 | 410 | dry | 49 |
Fmoc-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-resin | 3 | 238 | dry | 1 |