Table 3. Stability Comparison of Trimers (All Experiments Were Conducted at Room Temperature in DMF with 15.67 g Solvent/g Resin Amount).
peptide structure | nomenclature | time to reach 50% self-deprotection conversion (h) | desXaaXaa (%) |
---|---|---|---|
Fmoc-Pro-Pro-Ser(tBu)-resin | SPP | 13 | 73 |
Fmoc-Ala-Pro-Ser(tBu)-resin | SPA | 66 | 37 |
Fmoc-Pro-Ala-Ser(tBu)-resin | SAP | 175 | 0 |
Fmoc-Gly-Pro-Ser(tBu)-resin | SPG | 70 | 41 |
Fmoc-Pro-Gly-Ser(tBu)-resin | SGP | 275 | 0 |