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. 2022 Dec 6;7(50):46809–46824. doi: 10.1021/acsomega.2c05915

Table 3. Stability Comparison of Trimers (All Experiments Were Conducted at Room Temperature in DMF with 15.67 g Solvent/g Resin Amount).

peptide structure nomenclature time to reach 50% self-deprotection conversion (h) desXaaXaa (%)
Fmoc-Pro-Pro-Ser(tBu)-resin SPP 13 73
Fmoc-Ala-Pro-Ser(tBu)-resin SPA 66 37
Fmoc-Pro-Ala-Ser(tBu)-resin SAP 175 0
Fmoc-Gly-Pro-Ser(tBu)-resin SPG 70 41
Fmoc-Pro-Gly-Ser(tBu)-resin SGP 275 0