Table 4. ADME Properties of Compounds 9a–i.

Compd	MW (Da)	No. of H-bond acceptors	No. of H-bond donors	MR cm3	TPSA (Å)	iLOGP	GI absorption	Pgp substrate	CYP3A4 inhibitor	Bio availability score
9a	433.45	6	0	116.95	40.58	3.54	High	Yes	Yes	0.55
9b	512.34	6	0	124.65	40.58	4.03	Low	Yes	Yes	0.17
9c	467.89	6	0	121.96	40.58	3.94	Low	Yes	Yes	0.55
9d	447.47	6	0	121.92	40.58	3.81	Low	Yes	Yes	0.55
9e	458.46	7	0	121.67	64.37	3.26	High	Yes	Yes	0.55
9f	458.46	7	0	121.67	64.37	3.72	High	Yes	Yes	0.55
9g	458.46	7	0	121.67	64.37	3.65	High	Yes	Yes	0.55
9h	469.43	8	0	116.87	40.58	3.64	Low	Yes	Yes	0.55
9i	452.43	8	0	114.71	53.47	3.46	High	Yes	Yes	0.55