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. 2022 Dec 8;12:1055648. doi: 10.3389/fonc.2022.1055648

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Copyright © 2022 Li, Li, Gao, Zhao, Guo, Liu, Yin, Zhao and Yue

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Malignant epithelial marker FAM83D overexpression is associated with a poor prognosis in OC. (A) The tSNE plot of nine subgroups generated from malignant epithelial cells. (B) The circle chart showed the number and intensity of interaction between different cell subgroups. The size of the circle is proportional to the number of cells in cell subgroups. (C) GSVA analysis score of S0-S8 in hallmark pathway. (D) The Venn diagram shows the intersection gene of S5 top100 Markers and riskscore model. (E) Positive expression ratio of FAM83D in S0-S8. (F) qRT-PCR and Western blot analysis of FAM83D expression in the ovarian cell lines and the normal ovarian cell line OSE. The right panel, the level of proteins was quantified by gray analysis. *P < 0.05 vs. OSE cells (t-test, N = 3). (G) The expression levels of FAM83D between OC and adjacent tissues in the Oncomine database. (H) The GSEA shows the high FAM83D group was associated with the G2M checkpoint and WANG_CISPLATIN_RESPONSE_AND_XPC_UP in the TCGA OC dataset. (I) Kaplan–Meier plots indicate the overall survival and progression-free survival for OC patients categorized by FAM83D expression. (J) FAM83D was related to survival in different subgroups (grade, stage, etc.) of OC patients.