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. 2022 Dec 19;11(12):2497. doi: 10.3390/antiox11122497

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of PBE, SCOP, DL-AP5, and CNQX on long-term potentiation (LTP) in organotypic hippocampal tissue from 7-day-old male SD rats (n = 6). (A) Time course of LTP from all recordings in control and PBE (25, 50, and 100 mg/L) groups, (C) time course of LTP in control, SCOP (300 μM), and SCOP with 50 mg/L of PBE, (E) time course of LTP in the control, DL-AP5 (50 μM) and DL-AP5 with PBE50, and (G) time course of LTP in the control, CNQX (10 μM) and CNQX with PBE50. (B,D,F,H) Average LTP amplitude measured at 30–40 min after high-frequency stimuli (HFS). fEPSP, field excitatory postsynaptic potential. Tukey’s honestly significant difference test: *** p < 0.001 vs. control and ^## p < 0.01 vs. SCOP.