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. 2022 Nov 23;11(12):2315. doi: 10.3390/antiox11122315

Figure 3.

Figure 3

TRPV4 blockade alleviates OA by targeting M1 macrophages. (a) Immunofluorescence of iNOS in the synovium of the sham, MMT, MMT + GSK101, and MMT + HC067047 group. (Scale bars: 10 μm). (b) SO (safranin O/Fast Green) staining of knee joints from the sham, MMT, MMT + GSK101, and MMT + HC067047 groups (Scale bars: 100 μm). (c) HE staining of synovium from each of the 4 groups (Scale bars: 100 μm). (d) Images of reconstructed knee joints from each study group (Scale bars: 100 μm) (e) Percentages of iNOS-positive cells of animal sample. n = 5. One-way ANOVA with Tukey’s post-hoc test, **** p < 0.0001; ns = no significance. (f) Analysis of the OARSI score quantitatively in the 4 groups. n = 5. One-way ANOVA with Tukey’s post-hoc test, *** p < 0.001. (g) Synovitis grade quantification. n = 5. One-way ANOVA with Tukey’s post-hoc test, ** p < 0.01; *** p < 0.001; ns = no significance. All data are shown as mean ± SD.