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[Preprint]. 2022 Dec 16:2022.12.16.520799. [Version 1] doi: 10.1101/2022.12.16.520799

Figure 5. Antibodies elicited by MR-CoV-S6p312 are sensitive to amino acid substitutions present in SARS-CoV-2 variants.

Figure 5.

Neutralizing activity against SARS-CoV-2 variants. Serum samples from animals vaccinated once with MR-CoV-S6p312 were assessed for neutralizing antibody responses against pseudoviruses bearing the SARS-CoV-2 spike from different variants. Black dots represent individual mouse sera, and bars and error bars depict the geometric mean ± geometric standard deviation, respectively. Statistical analysis among groups was calculated by one-way ANOVA with Dunnett’s post test (ns, p>0.05; *, p<0.05; ****, p<0.0001).