Table 2.
Overall numbers and percent of pooled numbers for hospitalization and totals
| study | total | total ccp | total control hosp | total control | totals | CCP % | control % | ARR % (95% CI) | RRR %(95% CI) | Significance level | NNT Benefit |
|---|---|---|---|---|---|---|---|---|---|---|---|
| mITT (all cause hospitalizations) | 111 | 1305 | 160 | 1315 | 2620 | 8.5 | 12.2 | 3.7 (1.3, 6.0) | 30.1 (12.0, 44.4) | P = 0.0011 | 27 |
| mITT minus admit on screen | 88 | 1282 | 147 | 1302 | 2584 | 6.9 | 11.3 | 4.4 (2.2, 6.6) | 39.2 (21.7, 52.8) | P = 0.0001 | 23 |
| onset <= 5 days | 70 | 787 | 114 | 775 | 1562 | 8.9 | 14.7 | 5.8 (2.6, 9.0) | 39.5 (19.9, 54.3) | P = 0.0002 | 17 |
| onset >=6 days | 41 | 518 | 46 | 540 | 1058 | 7.9 | 8.5 | 0.6 (−2.7, 3.9) | 7.1 (−39.1, 37.9) | P = 0.3605 | 166 |
| donor titer >= median | 49 | 687 | 157 | 1315 | 2002 | 7.1 | 11.9 | 4.8 (2.2, 7.4) | 40.3 (18.8, 56.1) | P = 0.0004 | 21 |
| donor titer below median | 62 | 593 | 157 | 1315 | 1908 | 10.5 | 11.9 | 1.5 (−1.5, 4.5) | 12.4 (−15.6, 33.7) | P = 0.1735 | 67 |
| Low titer and onset <= 5 days, High titer and onset > 5 days, Low titer and onset > 5 days | 75 | 836 | 160 | 1315 | 2151 | 9.0 | 12.2 | 3.2 (0.6, 5.8) | 26.3 (4.4, 43.2) | P = 0.0105 | 31 |
Abbreviations. CCP=covid-19 convalescent plasma; mITT=modified intention to treat; Absolute risk reduction=ARR; RRR=RRR; hosp=hospitalizations; NNT=Number needed to treat