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. 2022 Dec 19;11(12):1842. doi: 10.3390/antibiotics11121842

Table 1.

In silico identification of the antimicrobial activities of sulforaphane (SFN) and fluconazole (FLZ).

SFN FLZ
Antimicrobial Activities Pa Pi Antimicrobial Activities Pa Pi
Anti-Helicobacter pylori 0.742 0.002 Lanosterol 14 alpha demethylase inhibitor 0.846 0.001
Yeast RNA Inhibitor 0.444 0.019 Steroid synthesis inhibitor 0.744 0.001
Glycoprotein-phosphatidylinositol inhibitor 0.516 0.093 Antifungal 0.726 0.008
Antiparasitic 0.441 0.023 Phospholipid translation ATPase Inhibitor 0.480 0.069
Omptin inhibitor 0.469 0.091 NADPH-cytochrome-c2 reductase inhibitor 0.366 0.134
Phospholipid translation ATPase Inhibitor 0.363 0.140 Sugar-phosphatase inhibitor 0.356 0.148
Endopeptidase So inhibitor 0.327 0.101 Cell wall synthesis inhibitor 0.351 0.002
Mannose isomerase inhibitor 0.302 0.071
P. gingivalis TPR protease inhibitor 0.301 0.108

Pa: probability of a compound being active; Pi: probability of a compound being inactive.