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. 2022 Nov 30;11(12):2376. doi: 10.3390/antiox11122376

Figure 7.

Figure 7

rCT-NAMPT relieves chronic DSS-induced colitis in a mouse model. (A) Scheme of the chronic colitis model subjected to 3% DSS with rCT-NAMPT (50 μg/kg). (B) Mice survival was tracked for 9 weeks, and mortality was calculated for n = 15 mice per group. The statistical differences between the rVehicle-treated animals are noted (log-rank test). The data come from two different experiments that yielded comparable results. (C) Weight loss of rVehicle, rCT or rCT-NAMPT in mice (n = 15). (D) Image (upper) and length (lower) of colon in 3% DSS-induced chronic colitis mice with rVehicle, rCT or rCT-NAMPT. (E) H&E staining of the colon (left) (n = 8): a representative image. H&E staining was used to evaluate histopathology scores in 3% DSS-induced chronic colitis mice with rVehicle, rCT, or rCT-NAMPT. The Student’s t-test with the Bonferroni adjustment was used to establish statistical significance when compared to rVehicle (*** p < 0.001).