Table 2.

Macrophage DEG analysis result summary for the genes involved in the NLRP3 inflammasome activation via the redox signaling pathway.

Genes	SCP259 (# Macrophages: 13888)					GSE182270 (# Macrophages: 555)
	p.val	p.val.adj	logFC	pct.test	pct.ctrl	p.val	p.val.adj	logFC	pct.test	pct.ctrl
NAMPT	2.64 × 10−13	4.80 × 10−09	0.72	0.36	0.34	0.0011	1	0.32	0.88	0.82
CYBB	7.57 × 10−21	1.37 × 10−16	0.71	0.39	0.34	4.19 × 10−06	0.141	0.62	0.66	0.48
NCF1	3.79 × 10−65	6.87 × 10−61	−0.43 *	0.29	0.53	0.049602	1	−0.27 *	0.39	0.51
NCF2	7.77 × 10−11	1.41 × 10−06	0.53	0.24	0.20	0.001618	1	0.54	0.51	0.37
NCF4	1.7 × 10−132	3.1 × 10−128	−0.86 *	0.21	0.49	0.001578	1	−0.53 *	0.33	0.47
P2RY6	6.00 × 10−87	1.1 × 10−82	−0.67	0.09	0.26	2.23 × 10−05	0.752	−0.59	0.21	0.41
SOD2	6.58 × 10−12	1.2 × 10−07	0.489	0.51	0.522	5.89 × 10−19	1.9 × 10−14	1.074	0.901	0.653
N × AT1	0	0	1.171	0.798	0.585	3.21 × 10−12	1.1 × 10−07	0.467	0.971	0.874
HIF1A	1.63 × 10−16	2.9 × 10−12	0.790	0.196	0.135	0.002	1	0.624	0.48	0.358
TXNIP	7.71 × 10−70	1.4 × 10−65	0.985	0.455	0.312	0.025	1	−0.323 *	0.417	0.505
TXN	Not available					3.74 × 10−05	1	0.569	0.764	0.695
NLRP3	1.54 × 10−05	0.279	0.420	0.067	0.044	Not available
CASP1	0.026	1	0.298	0.329	0.346	Not available
IL1B	Not available					0.008	1	0.402	0.728	0.705
NFKB1	0.038	1	0.504	0.159	0.153	0.013	1	0.543	0.422	0.316
TNFAIP8	0.024	1	0.377	0.156	0.146	0.024	1	0.473	0.453	0.368
TNFAIP8L2	6.22 × 10−18	1.13 × 10−13	−0.306	0.131	0.212	0.001	1	−0.599	0.253	0.421
TNFRSF1B	3.36 × 10−17	6.11 × 10−13	0.714	0.277	0.218	0.011	1	0.611	0.436	0.368

P.val: p-value, P.val.adj: adjusted p-value, logFC: log fold change, pct.test/pct.control: ratio of the cells expressing the gene in the test and control group. * Not agree with the result from the other dataset, SCP259.