Table 1.

Microbiological determinants warranting MIC determination according to the EUCAST guidelines [11].

Microbiological Determinants	Bacteria of Concern	Antibiotic of Concern
Agar diffusion method as inappropriate for some antibiotics	Gram-positive bacteria Staphylococcus spp. Enterobacterales, P. aeruginosa, A. baumannii	Daptomycin Dalbavancin Oritavancin Telavancin Vancomycin Teicoplanin Fosfomycin iv Colistin
Absence of detection of the resistance level to β-lactams	Streptococcus pneumoniae (reduced susceptibility to penicillin strains) Haemophilus influenzae (BLNAR * strains)	β-Lactams
Detection of low-level antibiotic resistance	Salmonella sp.	Ciprofloxacin
MIC creep	Staphylococcus aureus	Vancomycin
Preserve broad-spectrum antibiotics	Enterobacterales	Piperacillin/tazobactam Cephalosporins

* beta-lactamase-negative ampicillin resistance.