Table 1.

Modulation of molecular targets of tumor-suppressor miRs upregulated by three to five CUR, EGCG, QUE, RES and GEN.

miRs	miR-16	miR-22	miR-34a	miR-141	miR-145	miR-146a	miR-200c
Polyphenols	CUR Yang et al. [9] EGCG Tsang et al. [10] QUE Sonoki et al. [11]; Zhao et al. [12] RES Hagiwara et al. [13]; Azimi et al. [14]	CUR Sun et al. [15]; Sreenivasan et al. [16]; Sibbesen et al. [17] EGCG Li et al. [18] QUE Zhang et al. [19]	CUR Guo et al. [20]; Sun et al. [21]; Toden et al. [22]; Sun et al. [15] EGCG Chakrabarti et al. [23]; Li et al. [18]; Chakrabarti et al. [24]; Toden et al. [25]; Mostafa et al. [26] GEN Hsieh et al. [27]; Xia et al. [28]; Chiyomaru et al. [29] RES Hagiwara et al. [13]; Otsuka et al. [30]; Kumazaki et al. [31]; Yao et al. [32]	CUR Toden et al. [33] EGCG Gordon et al. [34] GEN Chiyomaru et al. [35] RES Hagiwara et al. [13]	CUR Mirgani et al. [36]; Liu et al. [37] EGCG Toden et al. [25] GEN Wei et al. [38] QUE Zhou et al. [39] RES Sachdeva et al. [40]	CUR Wu et al. [41] GEN Li et al. [42] QUE Tao et al. [43]	CUR Toden et al. [33]; Soubani et al. [44] EGCG Toden et al. [25] RES Hagiwara et al. [13]; Dermani et al. [45]
Targets *	Bcl-2↓ CUR: Yang et al. [9]; EGCG: Tsang et al. [10] HOXA10↓ QUE: Zhao et al. [12]	SP1↓, ESR1↓ CUR: Sun et al. [15] Erbb3↓ CUR: Sreenivasan et al. [16] NCoA1↓, HDAC6↓, MYCBP↓, PTEN↓, CUR: Sibbesen et al. [17] Wnt1/β-catenin↓ QUE: Zhang et al. [19]	Bcl-2↓, Bmi-1↓ CUR: Guo et al. [20] Bcl-2↓, CDK4↓, Cyclin D1↓ CUR: Sun et al. [21] Cyclin D↓, c-Myc↓, CDK6↓, Bcl-2↓ CUR: Toden et al. [22] miR-92↓, miR-93↓, miR-106b↓, miR-7-1↑, miR-34a↑, miR-99a↑ EGCG: Chakrabarti et al. [23] EMT↓, RTCB↓, ROS↑ GEN: Hsieh et al. [27] HOTAIR↓ GEN: Chiyomaru et al. [29] Notch-1↓ GEN: Xia et al. [28] Sirt1↓ via E2F3 RES: Kumazaki et al. [31] HNRNPA1↓ RES: Otsuka et al. [30] Bcl-2↓ RES: Yao et al. [32]	EMT↓ CUR: Toden et al. [33] HOTAIR↓ GEN: Chiyomaru et al. [35] Cancer stemness↓ RES: Hagiwara et al. [13]	Oct4↓, SOX-2↓, Oct4B1↓, CUR: Mirgani et al. [36] Oct4↓, CD44↓, CD133↓, Cyclin D1↓, Cdk4↓ CUR: Liu et al. [37] c-Myc↓ EGCG: Toden et al. [25] ABCE1↓ GEN: Wei et al. [38] Caspase-3↑ QUE: Zhou et al. [39]	NF-κB↓ CUR: Wu et al. [41] EGFR↓ MTA-2↓, IRAK-1↓, NF-κB↓ GEN Li et al. [42] Caspase 3↑, Bax↑, EGFR↓ QUE: Tao et al. [43]	EMT↓ CUR: Toden et al. [33] PTEN↑, MT1-MMP↓ CUR: Soubani et al. [44] Cancer stemness↓ EGCG: Toden et al. [25] Cancer stemness↓ RES: Hagiwara et al. [13] EMT↓ via vimentin, ZEB1, E-cadherin RES: Dermani et al. [45]

* Targets upregulated and downregulated by polyphenols through upregulation of miRs are indicated by ↑ and ↓, respectively. Bcl-2; B-cell lymphoma 2, HOXA10; homeobox A10, SP1; specificity protein 1, ESR1; estrogen receptor alpha 1, Erbb3; Erb-b2 receptor tyrosine kinase 3, NCoA1; nuclear receptor coactivator 1, HDAC6; histone deacetylase 6, MYCBP; Myc binding protein, PTEN; phosphatase and tensin homolog deleted on chromosome 10, Wnt1; wingless and int-1, EMT; epithelial-mesenchymal transition, RTCB; RNA 2′,3′-cyclic phosphate and 5′-OH ligase, ROS; reactive oxygen species, HOTAIR; HOX transcript antisense RNA, Notch-1; Notch homolog protein 1, Sirt1; sirtuin 1, ABCE1; ATP-binding cassette E1, NF-κB; nuclear factor-κB, EGFR; epidermal growth factor receptor, MTA-2; metastasis-associated 2, Bax; Bcl2-associated X protein, MT1-MMP; membrane type 1-matrix metalloproteinase, Bmi-1; B-cell-specific Moloney murine leukemia virus integration site 1, CDK; cyclin-dependent kinase, E2F3; E2F transcription factor 3, HNRNPA1; heterogeneous nuclear ribonucleoprotein A1, Oct4; octamer-binding transcription factor 4, SOX-2; SRY [sex determining region Y]-box 2, ZEB1; zinc finger E-box binding homeobox 1.