Table 3.

miRs upregulated by one of five dietary polyphenols and their proposed targets *.

CUR		EGCG	GEN	QUE	RES
miR-7 SET8↓, Bcl-2↓, p53↑ [80]; Skp2↓, p57↑, p21↑ [81] miR-9 AKT↓, FOXO1↓ [82]; GSK-3β↑, β-catenin↑, Cyclin D1↓ [83] miR-15a Bcl-2↓ [9]; WT1↓ [84] miR-16-1 WT1↓ [84] miR-28-5p BECN1↓ [85] miR-29a DNMT1↓, 3A↓, 3B↓ [86] miR-30c-5p MTA1↓ [87] miR-33b HMGA2↓ [88]; XIAP↓ [89] miR-98 LIN28A↓, MMP2↓, MMP9↓ [90] miR-99a JAK1↓, STAT1↓, STAT3↓ [91] miR-101 EZH2↓, EpCAM↓ [92]; Notch1↓ [93]; EZH2↓ [94] miR-124 Midkine↓ [95]	miR-125a ERRα↓ [96] miR-138 Smad4↓, NF-kB↓, Cyclin D3↓ [97] miR-143 NF-kB↓ [98]; PGK1↓ [99]; Autophagy via ATG2B↓ [100] miR-181b CXCL1↓ [101] miR-185 DNMT1↓, 3A↓, 3B↓ [86] miR-192-5p XIAP↓ [102]; PI3K↓, AKT↓ [103]; Wnt/β-catenin↓ [104] miR-196b ** BCR-ABL↓ [55] miR-206 mTOR↓, AKT↓ [105] miR-215 XIAP↓ [102] miR-340 XIAP↓ [106] miR-384 circ-PRKCA↓ [107] miR-491 PEG10↓ [108] miR-593 MDR1↓ [109]	miR-15b STIM2↓, Orai1↓ [110] miR-29b KDM2A↓ [111] miR-485-5p RXRα↓ [112] let-7b HMGA2↓ [113]	miR-574-3p RAC1↓, EGFR↓, EP300↓ [114] miR-1469 Mcl1↓ [115] let-7d THBS1↓ [116]	miR-1-3p TAGLN2↓ [117] miR-16-5p WEE1↓ [118] miR-22 Wnt1↓ [19] miR-34a-5p SNHG7↓ [119] miR-142-3p HSP70 ↓ [120] miR-197 IGFBP5↓ [121] miR-200b-3p Notch1↓ [122] miR-217 KRAS↓ [123] miR-503-5p Cyclin D1↓ [124] miR-1254 CD36↓ [125] miR-1275 IGF2BP1↓, IGF2BP3↓ [126] let7-a KRAS↓ [127] let-7c Numbl/Notch1↑ [128]	miR-424-3p Galectin-3↓ [129]

* Upregulation (↑) and downregulation (↓) of miR targets by polyphenols are indicated. ** Downregulation by RES is reported [130]. SET8; SET domain-containing lysine methyltransferase 8, Bcl-2; B-cell lymphoma 2, Skp2; S-phase kinase-associated protein 2, AKT; AKT serine/threonine kinase 1, FOXO1; forkhead Box O1, GSK-3β; glycogen synthase kinase-3 beta, WT1; Wilms’ tumor-1, BECN1; beclin 1, DNMT; DNA methyltransferase, MTA1; metastasis-associated 1, HMGA2; high mobility group A2, XIAP; X-linked inhibitor of apoptosis, LIN28A; Lin-28 homolog A, MMP; matrix metalloproteinase, JAK1; Janus kinase 1; STAT; signal transducer and activator of transcription, EZH2; enhancer of zeste homolog 2, EpCAM; epithelial cell adhesion molecule, Notch1; neurogenic locus notch homolog protein 1, ERRα; estrogen-related receptor alpha, PGK1; phosphoglycerate kinase 1, ATG2B; autophagy-related 2B, CXCL1; chemokine (C-X-C motif) ligand 1, PI3K; phosphoinositide-3 kinase, Wnt; wingless and int-1, BCR-ABL; BCR-ABL fusion gene, mTOR; mammalian target of rapamycin, circ-PRKCA; circ_0007580, PEG10; paternally expressed gene 10, MDR1; multidrug resistance mutation1, STIM2; Stromal interaction molecule 2, Orai1; ORAI calcium release-activated calcium modulator 1, KDM2A; lysine demethylase 2A, RXRα; retinoid X receptor alpha, RAC1; ras-related C3 botulinum toxin substrate 1, EGFR; epidermal growth factor receptor, EP300; E1A-associated protein P300, THBS1; thrombospondin 1, TAGLN2; transgelin 2, WEE1; WEE1 G2 checkpoint kinase, SNHG7, small nucleolar RNA host gene 7, HSP; heat shock protein, IGFBP; insulin-like growth factor binding protein, KRAS; KRAS proto-oncogene, GTPase, Numbl; NUMB like endocytic adaptor protein, Mcl1; myeloid cell leukemia 1, IGF2BP; insulin-like growth factor 2 mRNA binding protein.