Table 4.

miRs downregulated by one of six dietary polyphenols and their targets *.

CGA	CUR	EGCG	GEN	QUE	RES
miR-17 p21↑, G0/G1 arrest↑ [46]	miR-19a,b PTEN↑ [131] miR-125a-5p TP53↑ [132] miR-130a Nkd2↑ [133] miR-7641 p16↑ [134]	miR-98-5p CTR1↑ [135]	miR-23b-3p PTEN↑ [136] miR-151a-5p CASZ1↑, IL1RAPL1↑, SOX17↑, N4BP1↑, ARHGDIA↑ [137] miR-155 PTEN↑ [73] miR-221 miR-222 ARHI↑ [78] miR-223 Fbw7↑ [138] miR-223 E-cadherin↑ [139] miR-873-5p FOXM1↓ [140] miR-1260b sFRP1↑, Smad4↑, Dkk2↑ [141,142]	miR-30d-5p Notch↓ Wnt↓ [143]	miR-196b ** miR-1290 IGFBP3↑ [130]

* Upregulation (↑) and downregulation (↓) of miR targets by polyphenols are indicated. ** Upregulation by CUR is also reported [55]. PTEN; phosphatase and tensin homolog deleted on chromosome 10, Nkd2; naked cuticle homolog 2, CTR1; copper transporter 1, CASZ1; castor zinc finger 1, IL1RAPL1; interleukin 1 receptor accessory protein like 1, SOX17, SRY-box transcription factor 17, N4BP1; NEDD4-binding protein 1, ARHGDIA, rho-GDP dissociation inhibitor-alpha, ARHI; age-related hearing impairment, Fbw7; F-Box and WD repeat domain-containing 7, FOXM1; forkhead box M1, sFRP1; secreted frizzled-related protein 1, Smad; small mother against decapentaplegic, Dkk2; Dickkopf-related protein 2, Wnt; wingless and int-1, IGFBP; insulin-like growth factor binding protein.