Table 5.
Modulation of lncRs by six dietary polyphenols and targets affected by lncRs.
| lncR | Upregulation | Downregulation | Effects of Polyphenols on Proposed Targets of lncRs (↑, Upregulation; ↓, Downregulation) |
|---|---|---|---|
| AF085935 | EGCG [177] | Not specified | |
| AK001796 | RES [193] | Cell-cycle arrest↑ [193] | |
| AK294004 | CUR [156] | Cyclin D1↓ [156] | |
| CCAT1 | RES [205] | PI3K/AKT/mTOR↓ [206] | |
| DLEU2 | RES [194] | Cyclins E1 and D1↓ [195] | |
| GAS5 | CGA [152] CUR [157] |
miR-23a↓ by sponging [152] | |
| H19 | RES (at 50 μM) [196] | CUR [159,160,161] RES (at 200 μM) [162] |
Cell cycle arrest at S-phase↑ [196], p53↑ [160] EMT↓, invasion and migration via upregulating Snail [161] |
| HOTAIR | GEN [29,35,182,183] RES, [205] |
PI3K/AKT/mTOR signaling pathway↓ [184,185] | |
| KCNQ1OT1 | CUR [162] | Bcl-2↓ via miR-497 [162] | |
| LINC00511 | EGCG [111] | miR-29b↑ [111] | |
| LINC00691 | CUR [163] | AKT↓ [163] | |
| LINC-PINT | CUR [164] | Cell cycle arrest at G2/M↑ [164] | |
| MALAT1 | RES [196] | QUE [187,188,189] RES [197] |
Wnt/β-catenin signaling↓ [197] |
| MEG3 | CUR [165,167] | PTEN↑ [167] | |
| NEAT1 | EGCG [135,178] | EGCG [179] QUE [190] RES [198] |
ERK1/2↓ [178] miR-98-5p↑ [135] by sponging Cancer cell stemness↓ [179] |
| NRB2 | CUR [168] | AMPK/mTOR pathway↑ [168] | |
| PANDAR | CUR [169] | Bax↑ via upregulation of PUMA [169,170] | |
| PCAT29 | RES [199] | PTEN↑ via downregulation of miR-494 [200] | |
| ROR | CUR [37,172] | Wnt/β-catenin↓ [172] Oct4↓ via sponging miR-145 [37] |
|
| SNHG7 | QUE [119] | AKT/mTOR↓ [191] | |
| SOX2OT variant 7 | EGCG [180] | Cancer cell stemness↓ in combination with doxorubicin [180] | |
| TTTY18 | GEN [186] | AKT↓ [186] | |
| TUG1 | CGA [153] | Not specified | |
| UCA1 | CUR [174] QUE [192] |
Wnt/mTOR↓ [174] c-Myc↓ by sponging miR-124 [175] |
|
| XIST | CUR [176] | p21↑ [176] |
PI3K; phosphatidylinositol 3-kinase, AKT; AKT serine/threonine kinase 1, mTOR; mammalian target of rapamycin, Bcl-2; B-cell lymphoma 2, PTEN; phosphatase and tensin homologs deleted on chromosome 10, ERK; extracellular signal-regulated kinase, AMPK; AMP-activated protein kinase, Bax; Bcl2-associated X protein, oct4; Octamer-binding transcription factor.