Figure 2.

Mitochondrial dysfunction in Alzheimer’s disease and mitochondria-based therapeutics mechanism. (A) Mitochondrial dysfunction in the pathogenesis of AD results in the loss of mitochondrial structure and function that affects axonal transport, hydrogen peroxide production, mitochondrial biogenesis and dynamics, mitophagy, ER-mitochondria interaction, mitophagy, energy production, and ROS generation, as well as causing oxidative stress. (B) Mitophagy as a potential therapeutic target for treating dementia.