Table 1.

The list of current ongoing trials therapies based on mitochondrial complex I inhibitors and others.

Therapy Type	Drug Name	Under	FDA Status
Small Molecule	Metformin	Alzheimer’s Disease	AD (Phase 2/3)
Supplement, Dietary, Small Molecule	Resveratrol	Alzheimer’s Disease Mild Cognitive Impairment	AD (Phase 3) MCI (Phase 4)
Supplement, Dietary	Epigallocatechin Gallate (EGCG)	Alzheimer’s Disease	AD (Phase 2/3)
Small Molecule	Dexpramipexole	Alzheimer’s Disease Amyotrophic Lateral Sclerosis	AD (Phase 2) ALS (Discontinued)
Small Molecule	Masitinib	Alzheimer’s Disease Amyotrophic Lateral Sclerosis	AD (Phase 3) ALS (Phase 3)
Passive Immunotherapy	TB006	Alzheimer’s Disease	AD (Phase 1)