Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed cross-feedback modulation model of ERAP1 and ERAP2 peptide trimming ERAP1 trims long peptides transported into the ER, long peptides may bind unproductively to inhibit ERAP2 activity against newly generated shorter peptide substrates. ERAP1 and ERAP2 cooperate to produce peptides of ideal length for antigen processing. ERAP2 can rescue ERAP1 octamer-dependent inhibition resulting from the overtrimming of epitopes by the combined activities of ERAP1 and ERAP2.
