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Schematic of actin glutathionylation in dendritic spines. Actin undergoes oxidative modification at the synapse during oxidative stress potentially affecting its assembly and interactions. S-glutathionylation of actin at Cys-374 residue in the presence of GSH affects its polymerization [119]. Actin-SSG formed is reversed effectively by Grx1 utilizing GSH and reducing equivalents of NADPH.
