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. 2022 Nov 22;11(12):2308. doi: 10.3390/antiox11122308

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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SNVs found in the putative COQ4 metal-liganding motif. (A) The metal-liganding motif (encompassing residues H163 to E179) is highlighted in red on the COQ4 model. (B) Locations of SNVs are depicted. Structural alignment of Alr8543 and COQ4 identifies the metal-liganding motifs in COQ4. Metal ions and oleic acid were obtained from this structural alignment. Residues are colored according to their corresponding SNVs in Figure 9. Mg²⁺ ions are designated as green spheres and Cl⁻ in yellow. Oleic acid is represented by the cyan structure.