Figure 14.

Alignment of AlphaFold-generated model of human COQ5 with existing yeast Coq5 crystal structures. (A) Superimposition of the human COQ5 model (shown in orange), adapted with permission from [39,54], and the crystal structure of AdoMet-bound yeast Coq5 (shown in blue, PDB: 4OBW). The first 47 residues of the AlphaFold model, which contains a disordered region with low confidence, were omitted for clarity. (B) Human COQ5 model with conserved methyltransferase motifs I-III and post-I highlighted in cyan and vertebrate insert in red. AdoMet (shown in green) was modeled via structural alignment with the crystal structure of AdoMet-bound yeast Coq5 using PyMOL.