Table 2.
The antileishmanial activity, cytotoxic effect, and selectivity index of the essential oil of stems from Croton linearis growing in Santiago de Cuba.
| Sample | Cytotoxicity | Anti-Leishmania Activity | |||
|---|---|---|---|---|---|
| Macrophages CC50% a ± SD b (µg/mL) |
Promastigotes IC50% c ± SD (µg/mL) |
Selectivity Index d | Amastigotes IC50% ± SD (µg/mL) |
Selectivity Index e | |
| CLS-EO | 49.0 ± 5.0 | 21.4 ± 0.1 | 2 | 18.9 ± 0.3 | 3 |
| Pentamidine® f | 11.7 ± 1.7 | 0.4 ± 0.1 | 29 | 1.3 ± 0.1 | 9 |
a: Median cytotoxic concentration; b: Standard deviation; c: Median inhibitory concentration; d: CC50/IC50%Promastigote; e: CC50/IC50%Amastigote; f Reference drug.