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. 2022 Dec 19;11(12):2499. doi: 10.3390/antiox11122499

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of hidrosmin treatment in vascular function of aorta and mesenteric arteries from db/db mouse model. Maximum responses to high K⁺ concentration in aorta (a) and mesenteric resistance arteries (MRAs) (b) from non-diabetic (db/m), untreated diabetic (db/db) and hidrosmin-treated diabetic (db/db + H) mice. Graphs represent individual data and the mean ± SEM of each group (db/m, n = 7; db/db, n = 8–9; db/db + H, n = 7) * p < 0.05 vs. db/m by Kruskal–Wallis, followed by Dunn’s post-test. (c–h) Concentration–response curves to phenylephrine (Phe), acetylcholine (Ach) and diethylamine NONOate (DEA-NO) of aortas (c,e,g) and mesenteric arteries (d,f,h). Graphs represent the mean ± SEM of the indicated number of animals per group. * p < 0.05 vs. db/m and # p < 0.05 vs. db/db by two-way ANOVA followed by Bonferroni’s post-test.

Effect of hidrosmin treatment in vascular function of aorta and mesenteric arteries from db/db mouse model. Maximum responses to high K⁺ concentration in aorta (a) and mesenteric resistance arteries (MRAs) (b) from non-diabetic (db/m), untreated diabetic (db/db) and hidrosmin-treated diabetic (db/db + H) mice. Graphs represent individual data and the mean ± SEM of each group (db/m, n = 7; db/db, n = 8–9; db/db + H, n = 7) * p < 0.05 vs. db/m by Kruskal–Wallis, followed by Dunn’s post-test. (c–h) Concentration–response curves to phenylephrine (Phe), acetylcholine (Ach) and diethylamine NONOate (DEA-NO) of aortas (c,e,g) and mesenteric arteries (d,f,h). Graphs represent the mean ± SEM of the indicated number of animals per group. * p < 0.05 vs. db/m and # p < 0.05 vs. db/db by two-way ANOVA followed by Bonferroni’s post-test.