Table 1.
Metabolic and biochemical parameters in non-diabetic (db/m), untreated diabetic (db/db) and hidrosmin-treated diabetic (db/db + H) mice. Data are expressed as mean ± SEM of n = 10 animals per group. * p < 0.05 vs. db/m analyzed separately by Mann–Whitney U test. Abbreviations: HDL-C, HDL cholesterol; LDL-C, LDL cholesterol; ASAT, aspartate aminotransferase; ALAT, alanine aminotransferase; BUN, blood urea nitrogen; UD, undetectable.
| Db/m | db/db | db/db + H | |
|---|---|---|---|
| Blood Glucose (mg/dL) | 139.3 ± 5.1 | 396.4 ± 25.9 * | 385.3 ± 26.0 |
| Body Weight (g) | 32.2 ± 0.46 | 52.8 ± 1.4 * | 50.4 ± 1.9 |
| Triglycerides (mg/dL) | 84.3 ± 11.5 | 94.3 ± 13.5 | 91.8 ± 11.3 |
| Total Cholesterol (mg/dL) | 88.6 ± 2.1 | 171.6 ± 10.2 * | 165.6 ± 7.6 |
| LDL-C (mg/dL) | UD | 26.3 ± 3.3 | 24.3 ± 2.7 |
| HDL-C (mg/dL) | 76.3 ± 1.6 | 128.5 ± 6.4 * | 125.9 ± 4.7 |
| ASAT (UI/L) | 111.2 ± 31.2 | 135.8 ± 11.1 | 125.8 ± 8.9 |
| ALAT (UI/L) | 39.3 ± 4.1 | 150.4 ± 18.0 * | 148.6 ± 17.1 |
| Urea (mg/dL) | 36.6 ± 1.3 | 42.0 ± 2.4 | 43.0 ± 1.3 |
| BUN (mg/dL) | 17.3 ± 0.6 | 19.6 ± 1.1 | 20.0 ± 0.6 |