TABLE 2.
Comparison of the virulence of K56-2 with that of K56orbA::tp in a chronic respiratory infection model
| Strain | Virulencea at p.i. day:
|
|||
|---|---|---|---|---|
| 7
|
28
|
|||
| CFU/ml/lung | % Pathology | CFU/ml/lung | % Pathology | |
| K56-2 | 1.5 × 106 ± 2.4 × 106 | 40.5 ± 4.2 | 2.4 × 105 ± 4.5 × 105 | 39.0 ± 4.7 |
| K56orbA::tp | 2.3 × 103 ± 1.3 × 103b | 35.7 ± 3.5 | 1.0 × 101 ± 2.1 × 101 | 11.5 ± 2.6c |
a
Values are means ± standard deviations for four animals.
b
K56orbA::tp was significantly different from K56-2 (P < 0.05) by analysis of variance (ANOVA) and Dunn's multiple comparisons test.
c
K56orbA::tp was significantly different from K56-2 (P < 0.05) by ANOVA.