Table 4.
FICI values of fluconazole and benzalkonium chloride in combination with either (−)-myrtenol or (+)-myrtenol against various isolates of C. albicans.
Strains | Fluconazole | Benzalkonium Chloride | ||||||
---|---|---|---|---|---|---|---|---|
Growth Repression | Biofilm Prevention | Growth Repression | Biofilm Prevention | |||||
(−)-Myrtenol | (+)-Myrtenol | (−)-Myrtenol | (+)-Myrtenol | (−)-Myrtenol | (+)-Myrtenol | (−)-Myrtenol | (+)-Myrtenol | |
C. albicans 722 | 1.25 | 1.25 | 0.37 | 0.40 | 0.50 | 0.50 | 1.25 | 0.31 |
C. albicans 761 | 1.25 | 1.25 | 0.37 | 0.50 | 0.75 | 0.50 | 0.38 | 0.50 |
C. albicans 661 FR | 1.25 | 0.75 | 1.25 | 1.25 | 0.75 | 0.38 | 1.25 | 0.50 |
C. albicans 672 FR | 0.27 | 0.50 | 0.28 | 0.50 | 0.75 | 0.50 | 0.38 | 0.75 |
C. albicans 688 FR | 1.25 | 0.75 | 0.26 | 1.25 | 0.50 | 0.50 | 0.75 | 0.75 |
C. albicans 701 FR | 0.28 | 0.27 | 0.75 | 0.75 | 0.75 | 0.75 | 0.50 | 0.38 |
C. albicans 703 FR | 0.38 | 0.27 | 0.31 | 4.25 | 0.75 | 0.50 | 0.75 | 0.75 |
C. albicans 748 FR | 1.25 | 0.27 | 0.26 | 1.25 | 0.75 | 0.50 | 0.75 | 0.50 |
C. albicans 762 FR | 1.25 | 0.27 | 1.25 | 1.25 | 0.38 | 0.50 | 0.50 | 0.38 |
C. albicans 763 FR | 0.27 | 0.50 | 0.75 | 0.30 | 0.50 | 1.25 | 0.75 | 0.50 |
Fraction of strains with shown synergy | 36% | 64% | 54% | 36% | 45% | 81% | 36% | 72% |