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. 2022 Dec 2;11(12):1743. doi: 10.3390/antibiotics11121743

Table 4.

FICI values of fluconazole and benzalkonium chloride in combination with either (−)-myrtenol or (+)-myrtenol against various isolates of C. albicans.

Strains Fluconazole Benzalkonium Chloride
Growth Repression Biofilm Prevention Growth Repression Biofilm Prevention
(−)-Myrtenol (+)-Myrtenol (−)-Myrtenol (+)-Myrtenol (−)-Myrtenol (+)-Myrtenol (−)-Myrtenol (+)-Myrtenol
C. albicans 722 1.25 1.25 0.37 0.40 0.50 0.50 1.25 0.31
C. albicans 761 1.25 1.25 0.37 0.50 0.75 0.50 0.38 0.50
C. albicans 661 FR 1.25 0.75 1.25 1.25 0.75 0.38 1.25 0.50
C. albicans 672 FR 0.27 0.50 0.28 0.50 0.75 0.50 0.38 0.75
C. albicans 688 FR 1.25 0.75 0.26 1.25 0.50 0.50 0.75 0.75
C. albicans 701 FR 0.28 0.27 0.75 0.75 0.75 0.75 0.50 0.38
C. albicans 703 FR 0.38 0.27 0.31 4.25 0.75 0.50 0.75 0.75
C. albicans 748 FR 1.25 0.27 0.26 1.25 0.75 0.50 0.75 0.50
C. albicans 762 FR 1.25 0.27 1.25 1.25 0.38 0.50 0.50 0.38
C. albicans 763 FR 0.27 0.50 0.75 0.30 0.50 1.25 0.75 0.50
Fraction of strains with shown synergy 36% 64% 54% 36% 45% 81% 36% 72%