Table 2.

Vancomycin dosing and PK/PD data.

Vancomycin Dose Requires Renal Dose Adjustment	IV: 30–60 mg/kg/Day ITT: 5–20 mg Daily IVT: 5–20 mg Daily
Indication/targeted organisms	Gram-positive organisms
PK/PD data	CSF/serum concentrations: ▪ Uninflamed meninges: 0 to 4 mg/mL ▪ Inflamed meninges: 6 to 11 mg/mL, ratio 80% Percent protein binding: 30–60% Serum half-life: 2–7 h Cmax: Variable AUC/MIC: >400

References [48,121,122,127].