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(A) Properly functioning nephron. (B) The mechanism of nephron impairment in the course of long-term, inappropriately treated DM. (C) Effect of SGLT2 inhibitor empagliflozin on improving intraglomerular pressure and GFR in DM [42]. SGLT1, SGLT2—sodium-glucose transport proteins, JGA—juxtaglomerular apparatus.
