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. 2022 Dec 12;12(12):1858. doi: 10.3390/biom12121858

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The SREBP/PPAR chimeric decoy ODN was effectively transferred in ear skin. (A) Structure of the synthetic SREBP/PPAR chimeric decoy ODN. (B) The transfer effectiveness of the SREBP/PPAR chimeric decoy ODN in ear skin (green). DAPI (blue)-stained nuclei. (C) Representative mouse ear skin lesion images. (D) The redness of the ear skin. (E) Single and chimeric decoy ODNs suppressed the protein expression of SREBP-1, PPAR-γ, and SCD-1. * p < 0.05 compared with the NC. † p < 0.05 compared with the CA+Scr.