Skip to main content
. 2022 Dec 12;12(12):1858. doi: 10.3390/biom12121858

Figure 4.

Figure 4

The SREBP/PPAR chimeric decoy ODN suppressed C. acnes-induced activation of pro-inflammatory cytokines. ELISA results demonstrating that the SREBP/PPAR decoy ODN suppressed the C. acnes-induced increased serum levels of (A) IL-1β and (B) IFN-γ. (C) Representative Western blot analysis results showing that the SREBP/PPAR decoy ODN inhibited the C. acnes-induced activation of pro-inflammatory cytokines. (D–F) Graphs showing the quantitative signal intensities of IFN-γ, TNF-α, and IL-1β after normalization with GAPDH. The results are expressed as mean ± SEM. * p < 0.05 compared with the NC. † p < 0.05 compared with the CA. ‡ p < 0.05 compared with the CA+Scr. Scale bar = 50 μm. NC, normal control; S/P, normal control treated with SREBP/PPAR chimeric decoy ODN; CA, group injected with living C. acnes; CA+Scr, group injected with living C. acnes and treated with Scr decoy ODN; CA+S/P, group injected with living C. acnes and treated with SREBP/PPAR chimeric decoy ODN.