Table 1.
Summary of SF biomaterials in skin wound healing.
| Author | Type of SF Dressing | Control Dressing | Dressed Wound | Healing Rate (p-Value) |
|---|---|---|---|---|
| [59] | Scaffold | No dressing | Random SF scaffold (RSS) |
p ≤ 0.01 on days 3 and 21, p ≤ 0.05 on day 14, p ≤ 0.001 on day 21 |
| Aligned SF scaffold (ASS) |
p ≤ 0.05 on days 3, 7, 14 p ≤ 0.001 on day 21 |
|||
| [90] | Electrospun membrane | 3MTM TegadermTM | PDA-modified electrospun SF membrane (PESF) | p < 0.001 |
| Electrospun SF membrane (ESF) | Not significant | |||
| [60] | Electrospun scaffold | No dressing | Electrospun SF scaffold | p < 0.05 |
| [91] | Electrospun scaffold | Linitul® | Electrospun SF scaffolds cellularized with human Wharton’s jelly MSCs (Wj-MSCs-SF) | - |
| [18] | Sol-gel film | No dressing (control group), Mepitel® (positive control) |
Silkworm cocoonss ol-gel film (SCSF-90) |
p < 0.05 on day 5 p < 0.01 on days 10 and 15, compared to the control group |
| [95] | Hydrogel | 3MTM TegadermTM (control group), commercial chitosan dressing (positive control) | Heparinized SF hydrogel | - |
| Heparinized SF hydrogel with FGF1 (SF + FGF) | p < 0.001 on day 14, compared to the control group | |||
| [88] | Scaffold | - | Chitosan/SF (CS/SF) composite scaffold | - |
| [85] | Hydrogel | Soframycin gel (positive control) | Nanosilver-loaded SF (NSF) gel | p < 0.05 |
| [68] | Electrospun nanomatrix | Medical gauze (control group), Medifoam® (positive control) | Electrospun SF nanomatrix | - |
| [103] | Hydrogel | No dressing (control group), Purilon gel (positive control) |
SF hydrogel | p < 0.05 on days 9 and 12 compared to the Purilon gel |
| [104] | Hydrogel | TegadermTM film (control group), Col gel (positive control) |
SF hydrogel | p ≤ 0.01 compared to the control group |
| [110] | Sponge | Gauze | SF sponge dressing | - |
| Insulin-loaded SF sponge dressing | p < 0.05 after 1 and 2 weeks compared to the other groups | |||
| [62] | Sponge | SF sponge dressing | Insulin-loaded SF sponge dressing | p < 0.01 on days 5 and 11 |
| [111] | Scaffold | No dressing | SF | - |
| NT/SF | - | |||
| NT/GMs/SF | p < 0.05 on days 14, 21, and 28 | |||
| [113] | Hydrogel | Gauze (control group), SFH (4% SF; positive control) |
SFMH (4% SF with 0.01% melanin) | - |
| SFCH (4% SF, 0.01% melanin, and 0.1% of berberine) | - | |||
| [114] | Electrospun scaffold | No dressing (control group), SF scaffold (positive control) | SF patches cellularised with human adipose-derived mesenchymal stromal cells (Ad-MSCs-SF) |
p < 0.05, on days 3 and 10 compared to the control group |
| Decellularized (D-Ad-MSCs-SF) | p < 0.05, on days 3 and 10 compared to the control group | |||
| [17], clinical study | Film | Commercial dressing Sidaiyi (SF sponge-silicone, two-layered scaffold) | SF film | p = 0.015 |