Table 1.
Inflammation and endothelial dysfunction in a nutritional model of nonalcoholic fatty liver disease.
| Variables # | Control | NAFLD | NAFLD+LOLA | NAFLD+VitE | NAFLD+LOLA+VitE | p * |
|---|---|---|---|---|---|---|
| IL-1β (pg/mL) | 7.92 (0.69–15.16) | 5.50 (1.49–9.51) | 7.87 (2.0−13.73) | 9.04 (3.30–14.79) | 10.12 (1.17–19.06) | 0.843 |
| IL-6 (pg/mL) | 191.75 (36.93–994.25) | 116.15 (13.96–439.46) | 90.94 (25.47–149.70) | 113.67 (13.96–217.46) | 22.20 (1.96–994.25) | 0.165 |
| TNF-α (pg/mL) | 5.21 (1.44–8.99) | 3.49 (2.71–4.25) | 4.02 (2.58−5.46) | 4.56 (3.28–5.85) | 3.39 (1.90–4.87) | 0.580 |
| IL-10 (pg/mL) | 33.17 (19.93–49.62) | 56.07 (29.12–91.3) | 44.66 (24.88–76.66) | 53.55 (29.12–76.84) | 48.05 (27.53–66.41) | 0.062 |
| MCP-1 (pg/mL) | 317.39 (252.11–382.66) a | 433.32 (356.65–510.0) a,b | 395.64 (259.58–531.70) a,b | 523.19 (450.96–595.42) b | 453.10 (317.08–588.92) a,b | 0.037 |
| e-selectin (ng/mL) | 1.72 (1.42–2.03) a | 2.38 (1.95–2.80) a,b | 2.52 (2.22–2.82) b | 2.20 (1.76–2.65) a,b | 2.43 (2.0–2.87) b | 0.015 |
| ICAM-1 (ng/mL) | 0.14 (±0.03) a | 0.46 (±0.15) a,b | 0.67 (±0.15) b | 0.60 (±0.18) b | 1.06 (±0.40) b | <0.001 |
| PAI-1 (pg/mL) | 42.56 (18.24–66.88) | 46.28 (29.04–63.52) | 106.26 (29.57–182.94) | 89.25 (43.46–135.03) | 122.80 (19.78–225.80) | 0.170 |
| Insulin (pg/mL) | 381.52 (±74.72) a | 1750.39 (±498.76) b | 1170.23 (±264.63) a,b | 1023.09 (±204.90) a,b | 1880.82 (±326.98) b | <0.001 |
| Leptin (pg/mL) | 2227.51 (68.93–7502.01) a | 10119.70 (1203.67–25894.03) b | 7240.19 (3879.69–10600.70) a,b | 10807.54 (2779.80–18835.28) b | 11202.96 (7618.65–14787.270) a | 0.025 |
| Adiponectina (ng/mL) | 15.32 (11.36–19.28) a | 35.45 (26.87–44.03) b | 37.31 (29.59–45.04) b | 37.91 (22.91–52.92) b | 30.05 (26.10–35.25) a,b | 0.001 |
# Variables expressed by mean (±standard deviation), or median (25th–75th percentiles). * p < 0.05 is considered significant, different letters indicate a significant difference between groups. Abbreviations: IL: interleukin, ICAM: intercellular adhesion molecule, LOLA: ornithine aspartate, MCP: monocyte chemoattractant protein, NAFLD: nonalcoholic fatty liver disease, PAI: plasminogen activator inhibitor, TNF: tumor necrosis factor, and VitE: vitamin E.